Frozen Section Evaluation of Methylene Blue Dye based Sentinel Lymph Node Biopsy in Early Breast Cancer – A Feasibility Pilot Study in a Tertiary Cancer Centre

  • Sangeetha K Nayanar Malabar Cancer Centre, (P.O) Moozhikkara, Thalassery, Kannur
  • Varadaraja R Perumal Malabar Cancer Centre, (P.O) Moozhikkara, Thalassery, Kannur
  • Satheesan Balasubramanian Malabar Cancer Centre, (P.O) Moozhikkara, Thalassery, Kannur
Keywords: Frozen section, Sentinel lymph node, Methylene blue dye, Early breast cancer

Abstract

Background: Most of the major cancer centres have adopted sentinel lymph node biopsy (SNLB) as standard means of axillary nodal assessment as an alternative to axillary lymph node dissection (ALND) in clinically node negative early breast cancers. The benefits of SNLB is to reduce the functional disability which is a potential consequence of ALND. A major pitfall of SNLB is the potential of false negative rate which will increase the risk of an axillary recurrence.
Methods: This is a pilot study of forty one cases of clinically N0, T1 and T2 tumors for whom sentinel lymph node mapping was done using methylene blue dye to detect occult metastasis. This was validated by complete ALND in all cases.
Results: The calculated accuracy of the frozen section analysis was 97.5%, sensitivity was 85.7% and specificity was 100%. Positive predictive value was100%, negative predictive value was 97.14% and false negative rate was 2.86%
Discussion & Conclusion: This study demonstrates a high sensitivity and specificity for frozen sections of SNLB with an accuracy of 96%.

Author Biographies

Sangeetha K Nayanar, Malabar Cancer Centre, (P.O) Moozhikkara, Thalassery, Kannur

Professor Division of Oncopathology, Clinical Laboratory services

Varadaraja R Perumal, Malabar Cancer Centre, (P.O) Moozhikkara, Thalassery, Kannur

Senior Resident Division of Oncopathology, Clinical Laboratory services

Satheesan Balasubramanian, Malabar Cancer Centre, (P.O) Moozhikkara, Thalassery, Kannur

Professor Department of Surgical Oncology

Published
2018-09-27
Section
Original Research